Abstract: Achieving advanced control of major hazard sources of gas is an important basis to ensure sound development of coal mining industry. With the gradual strengthening of the national demand for coal mine safety, the traditional mode of coal enterprises in cooperation with scientific research institutes has been difficult to adapt to it. In order to solve this problem, influence factors of professional synergetic management and control of major hazard sources of coal mine gas were analyzed. Then its evolutionary process was studied. On this basis, Professional synergetic management and control mode of major hazard of coal mine gas was proposed creatively. And the operating system which matched the pattern was established. The demand of both coal enterprises and research institutes were taken a full consideration in this mode. And new ways of deep collaboration of production and research of it was provided, which opened up new roads to speeding up transforming scientific and technological achievements. This mode has been successfully used and promoted in Shenhua group, which made significant economic and social benefits.